(c) Hybrid Medical Animation
We can mix up our strings of DNA (chromosomes) in a few ways. This week, we’ll talk about translocations.
We’ve talked about the correct number of chromosomes in a karyotype and banding. To refresh, humans have 46 chromosomes or 23 pairs of chromosomes in our regular (somatic cells). Eggs have 23 chromosomes and sperm have 23 so when they pair up, we get the full chromosome complement.
A chromosome translocation is when a piece of a chromosome is found on a different chromosomes (e.g. a piece of chromosome 7 is found on the tip of chromosome 11). You may have heard it described in fancier terms = abnormality due to rearrangement of pieces between nonhomologous chromosomes. Nonhomologous just means different chromosomes. We’ll go through the basic concepts – it’s easier than you think!